On 11 October 2024, the permission of the Ministry of Health of the Russian Federation was obtained to conduct clinical trials of a medicinal product (tissue engineering product) developed at IDB RAS, "Combined Biological Skin Equivalent (CombiBSE)" to assess safety and efficacy in the treatment of patients with heat injuries. The unique feature of the development of CombiBSE is the combination of donor mesenchymal stem cells and autologous keratinocytes of the patient in one product.

The research was conducted on the base of Government basic research program No. 0088-2023-0001 Theme "Development of biomedical cell products and creation of a pilot bank of tissue and cell transplants".

This clinical trial of a high-tech drug based on cultured human cells is the second in the Russian Federation.

Akrus Biomed Ltd. is an industrial partner of IDB RAS for the future clinical trials. Its novel industrial platform will become a place to produce samples of CombiBSE, which later will be proceed to multicenter randomized open-label clinical trials.

12 of April, 12:00. Conference Hall of IDB RAS.

Presentation of the book "Chemical Languages of Nervous Systems".

The book "Chemical Languages of Nervous Systems", written by a team of neurobiologists from the Institute of Developmental Biology of the Russian Academy of Sciences and a group of mathematicians from the Institute of Control Sciences of the Russian Academy of Sciences, has been published. Members of Neurobiology of Development Lab participated in the book writing are Dmitri Sakharov, Varvara Dyakonova and Dmitry Vorontsov. 

The book outlines a heterochemical concept of the nervous system's operation. According to this concept, the crucial role in the work of the nervous system is carried out by endogenously active neurons and assemblies capable of forming behavior even in the absence of external stimuli. The communication language between neurons and parts of the nervous system is chemically based. This language is based on a variety of signaling molecules - neurotransmitters and neurohormones - that act not only in synaptic clefts but throughout the intercellular space.

The book covers the evolution of the neurotransmitter language, the cellular mechanisms of behavior formation, neuromodulation, and the role of transmitters in behavior choice and adaptation to external changes. The mathematical formalization of this concept required fundamentally new approaches, to which the second part of the book is devoted.

Everyone is invited to the presentation!

Congratulations to our colleagues Ekaterina A. Malolina, Valery V. Mun, Marat S. Sabirov, and Andrey Yu. Kulibin on the paper published in “Nature Scientific Reports”!

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Special issue of “Biochemistry Moscow” (Volume 88, issue 11, November 2023) is dedicated to the memory of Alexey M. Olovnikov (1936-2022), the author of the Telomere theory of aging.

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